Cellular Invasion plays an important role in cancer initiation, tumor progression, metastasis and tissue remodeling. BIOENSIS' invasion assays are designed to quantify the efficacy of a compound’s capability to inhibit invasive metastatic and endothelial cell movement across a basement membrane.
BIOENSIS’ invasion assays are done in Boyden chamber transwells (96-well format) coated with a Basal Membrane Extract (BME). In this assay, cells are seeded on the apical chamber and incubated with a chemotractant (in the filler chamber) in the presence or absence of a test article. Quantitation of cellular migration/invasion is done by fluorometric quantification.
BIOENSIS’ Invasion/Migration assays:
• Flexible testing protocols for migration and invasion
• Compound testing done in Boyden chambers, IC50 and EC50 are provided
• Fluorometric or imaging detection
• Multiple cell lines available for testing
Please contact us to discuss your study, pricing and an up to date list of available cell lines